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. 2022 Jan 20;8:643958. doi: 10.3389/fcvm.2021.643958

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Copyright © 2022 Liu, Lou and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protein–protein interaction (PPI) network of hub genes. (A) The PPI network of the top 15 hub genes created by STRING; (B) PP1 networks and function analyses of the four downregulated hub genes; (C) PPI networks and function analyses of the 11 upregulated hub genes. Inner circles represent the input genes and outer circles correspond to GeneMANIA proposed hub genes, the size of the circles indicates the correlation with the input genes.