Skip to main content
. Author manuscript; available in PMC: 2022 Feb 3.
Published in final edited form as: Clin Sci (Lond). 2020 Jan 17;134(1):53–70. doi: 10.1042/CS20190794

Figure 9. A proposed model linking mTORC2 inhibition to decreased placental amino acid transport in human IUGR.

Figure 9.

The findings of the present study are consistent with the model that inhibition of placental mTORC2 in human IUGR reduces the Rac1 and Cdc42 expression, resulting in inhibition of actin signaling mediated transporter trafficking of amino acid transporter isoforms, which contributes to a decreased fetal amino acid supply and restricted fetal growth.