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. 2022 Jan 17;145(6):448–464. doi: 10.1161/CIRCULATIONAHA.121.056076

Figure 1.

Figure 1.

Cardiomyocyte-specific ablation of Rev-erb causes progressive and lethal heart failure. A, Echocardiography analysis in WT and KO male mice at 2.5 months of age, n=8 for WT and n=6 for KO. B, Echocardiography analysis in WT and KO male mice at 4.5 months of age, n=5 mice. C, Echocardiography analysis in WT and KO male mice at 6 months of age, n=4 mice. D, Representative M mode images at 6 months of age. E, Quantitative reverse transcription polymerase chain reaction analysis of the heart at 5 months of age, n=mice. F, Heart weight (HW) to tibia length (TL) ratio at 6 months of age, n=5 for WT and n=6 for KO. G, Representative gross picture of hearts at 6 months of age. H, Trichrome stain at 6 months of age. I, Survival of WT and KO female mice, n=13 for WT and n=10 for KO mice, the P value is based on the log-rank Mantel-Cox test. Data are mean±SEM. Each dot represents an individual mouse. *P<0.05 between groups by 2-sided t test. See Table S6 for statistical details. ANP indicates atrial natriuretic peptide; BNP, B-type natriuretic peptide; D;d, left ventricular dimension at end-diastole; D;s, left ventricular dimension at end-systole; EF, ejection fraction; FS, fractional shortening; KO, knockout; LVPWd, left ventricular posterior wall thickness at end-diastole; LVPWs, left ventricular posterior wall thickness at end-systole; and WT, wild type.