ROC for the RF classifier. The mean AUROC is obtained across all LOOCVs, and its performance in determining SCLC from all other lung nodules in (A) group A (NC) and (B) group B (CE) scans is shown. Note that the mean AUROC is > 0.8 in both groups, suggesting good discrimination of SCLC. AUROC, area under the receiver operating characteristic curve; CE, contrast-enhanced; LOOCV, leave-one-out-cross-validation; NC, noncontrast; RF, random forest; ROC, receiver operating characteristic curve; SCLC, small-cell lung cancer.