Table 5.

Adverse events in the study population.

Adverse events	No. of AEs (person-time)	% incidence (N = 384)
All adverse events	135	35.2
Menopause symptoms (hot flash/flush, sweat/night sweat)	69	18.0
Osteoporosis (muscle pain/bone pain)	21	5.5
Agrypnia	11	2.9
Dizziness	5	1.3
Tooth ache	3	0.8
Breast lump and pain	2	0.5
Spots	2	0.5
Hand numbness	2	0.5
Edema in limbs/facial swelling	2	0.5
Chest tightness	2	0.5
Others∗	16	4.2

AE = adverse event.

^∗Others included headache, premature ovarian failure, pelvic infection, left lower abdomen pain, neurasthenia breakdown, hair loss, hypertension, hearing loss, decreased response, irritable, fatigue, stiff neck, atony, abnormal liver function, increased levels of thirst, and leg muscle tremors.