Direct effects of one variable on another variable by specific PRO domains (eg, cancer experience on physical functioning, cancer experience on loneliness, loneliness on physical functioning, etc): (A) all significant direct effects between variables within physical functioning domain, (B) all significant direct effects between variables within pain interference, (C) all significant direct effects between variables within fatigue domain, (D) all significant direct effects between variables within anxiety domain, and (E) all significant direct effects between variables within depression domain. Values alongside the lines represent significant direct effects; *P < .05; **P < .01; ***P < .001. PRO, patient-reported outcome.