Table 2.

Genome-wide significant association signals in early-onset myasthenia gravis

Chr	Position (SNPid)	Nearest gene	EA/OA	Cohort	EAF	OR (95%CI)	P
6	31442744 (rs3093958)	HCP5/MICA	G/A	All	0.245/0.094	4.49 (3.62–5.57)	3.97 × 10−42
				M	0.117/0.094	1.90 (1.28–2.82)	1.47 × 10−3
				F	0.290/0.094	6.39 (5.01–8.14)	7.46 × 10−51
11	116158033 (rs73007767)	LINC02151	G/T	All	0.129/0.087	1.85 (1.48–2.30)	4.36 × 10−8
				M	0.133/0.087	1.80 (1.26–2.56)	1.14 × 10−3
				F	0.128/0.087	1.81 (1.42–2.32)	2.17 × 10−6

Positions are in build hg38; Chr, chromosome; EA/OA, effect allele/other allele; EAF, effect allele frequency in cases and controls; meta-analysis is based on early-onset myasthenia gravis cases from the US and Italian cohorts (595 cases and 2,718 controls).