Table 4.

Causal genes associated with myasthenia gravis based on TWAS of skeletal muscle

			MAF		eQTL		TWAS
	Chr	ID	Cases	Cont.	Z	GWAS.Z	Z	P	PERM.P	PPH4
Overall
CHRNB1	17	rs4151121	0.433	0.372	−11.79	4.39	−4.67	3.01 × 10−6	2.03 × 10−4	0.98
ERBB2	17	rs2102928	0.353	0.322	−3.42	2.16	−5.00	5.63 × 10−7	7.99 × 10−4	0.18
Early-onset
CYP21A2	6	rs3101018	0.225	0.089	4.55	12.72	10.90	7.32 × 10−28	3.76 × 10−3	0.98
HLA-DMA	6	rs35404844	0.061	0.042	7.12	3.58	7.60	2.88 × 10−14	1.13 × 10−3	0.89
Late-onset
C2	6	rs1048709	0.180	0.180	−3.97	4.51	−6.80	1.04 × 10−11	1.23 × 10−3	0.71
HLA-DRB5	6	rs9271055	0.180	0.158	16.95	5.46	7.68	1.65 × 10−14	5.05 × 10−3	0.00

Chr, chromosome; ID, rs number of the best eQTL locus in the locus; MAF, minor allele frequency; cont., controls; eQTL Z, Z-score of the best eQTL in the locus; GWAS.Z, GWAS Z-score for the eQTL; PERM.P, TWAS permutation P values; PPH4, Bayesian derived posterior probability for colocalization of the eQTL and the GWAS variant.