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. 2022 Feb 1;11(1):2029298. doi: 10.1080/2162402X.2022.2029298

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© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — MUC1-C and NuRD drive STAT1 and IRF1 expression. (a and b). DU-145/tet-MUC1shRNA cells treated with vehicle or DOX for 7 days were analyzed for the indicated mRNA levels (a). The results (mean ± SD of 4 determinations) are expressed as relative mRNA levels compared to that obtained for vehicle-treated cells (assigned a value of 1). Lysates were immunoblotted with antibodies against the indicated proteins (b). (c). Lysates from DU-145 cells expressing a CsgRNA or MUC1sgRNA#1 were immunoblotted with antibodies against the indicated proteins. (d). DU-145/tet-MUC1shRNA cells treated with vehicle or DOX for 7 days were stimulated with 10 ng/ml IFN-γ for 24 hours. Lysates were immunoblotted with antibodies against the indicated proteins. (e). Lysates from DU-145 expressing a CshRNA, ARID1AshRNA, MTA1shRNA or MBD3shRNA were immunoblotted with antibodies against the indicated proteins. (f and g). Genome browser snapshots of ATAC-seq data from the STAT1 (f) and IRF1 (g) genes in DU-145/tet-MUC1shRNA cells treated with vehicle or DOX for 7 days.