Figure 8.

MUC1 associates with CSC and IFN signatures in individual CRPC cells. (a). Imputed expression of MUC1 and select genes associated with CSC (SOX2, NANOG, KIT, KLF4, EZH2, ARID1A), interferon signaling (STAT1, IRF1, IFNGR1, IFNGR2), and androgen signaling (AR, KLK3, TMPRSS2, NKX3-1, DPP4). (b). Heatmap depicting CRPC cell expression of candidate genes associated with AR signaling, NEPC, CSC and interferon signaling. (c). Single-cell enrichment was performed for curated AR and CSC signatures and select HALLMARK pathways. Correlation of enrichment scores amongst pathways and MUC1 expression is shown. (d). Correlation analysis of candidate gene expression with MUC1 expression across CRPC cells. CSC signature enrichment across cells is displayed as blue to red scale.