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. 2022 Feb 1;11(1):2032918. doi: 10.1080/2162402X.2022.2032918

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© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — TNFSF15 promotes M1 macrophages infiltration into the tumor. A The picture of TNFSF15-overexpressing LLC tumors (TNFSF15) and the control tumors (Mock) on day 14, n = 8. The volume (b) and weight (c) measurement of TNFSF15 and Mock tumors, n = 8. D The weight of mice was monitored from day 5 to day 14, n = 8. E Flow cytometric analysis of macrophages (CD45⁺CD11b⁺F4/80⁺), M1 macrophages (CD45⁺CD11b⁺F4/80⁺MHCII⁺CD206⁻), M2 macrophages (CD45⁺CD11b⁺F4/80⁺MHCII⁻CD206⁺) in tumor. Quantification of the percentages of macrophages within CD45⁺ fraction (f), M1 macrophages, and M2 macrophages within CD45⁺CD11b⁺F4/80⁺ fraction (g) in TNFSF15 and Mock tumors, n = 8. H Flow cytometric analysis and quantification of CD86⁺ macrophages within CD45⁺ fraction in TNFSF15 and Mock tumors, n = 8. I qPCR analysis of gene expression of F4/80, H2Ab1 (MHCII) and CD86 in TNFSF15 and Mock tumor tissues, n = 6. The data are presented as the mean ± SD, *P < .05, **P < .01, ***P < .001.