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Twelve CNS regions showed significant associations between severity of TDP-43 pathology and C9orf72 expansion in ALS. Lateral (a), sagittal (b), cross-sectional (c), and coronal (d, e) sections of CNS regions are shown. Colors reflect the effect size (calculated coefficients) for presence of a C9orf72 expansion on TDP-43 pathology across all ALS cases, ranging from weak effects (light red) to strong effects (dark red). Spinal cord is not shown. See Table 5 for additional details.
