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. 2021 Apr 29;10(1):810–821. doi: 10.1080/22221751.2021.1917309

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Cross-inhibitory activity of coronavirus fusion inhibitors against HIV-1. (A) Inhibition of EK1 and EK1V1 on HIV-1_NL4-3 Env-mediated cell–cell fusion was determined by a dual-split protein (DSP)-based cell fusion assay. The inhibitory activities of EK1 and EK1V1 against the pseudoviruses of HIV-1_NL4-3 (B), H5N1 (C), H7N9 (D), RSV (E), and VSV (F), were determined by a single-cycle infection assay. Both the cell fusion and pseudovirus infection assays were repeated at least three times, and data are expressed as means ± standard deviations (SD) while the mean IC₅₀ values are shown.