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. 2022 Feb 1;11(1):391–405. doi: 10.1080/22221751.2022.2026198

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Inhibition of β-catenin/TCF1 axis attenuates 6-BIO-triggered HIV-1 reactivation. (A) The expression of TCF/LEF family members. ACH2 cells (1×10⁶) were treated with 6-BIO (1 μM) for 24 h, the expression of TCF1, TCF3, TCF4, and LEF1 was quantified by real-time qPCR and the relative enhancement fold was calculated. (B, C) Interference with the β-catenin/TCF1 pathway attenuates 6-BIO-induced viral reactivation. The endogenous GSK3α, GSK3β, β-catenin, or TCF1 was knocked-down with lentiviruses containing specific shRNAs for 48 h (B), and cells were further treated with 6-BIO (1 μM) for additional 24 h and viral reactivation was detected and calculated (C). Result is one representative from five independent repeats. Data are presented as mean ± SD. *** P < 0.001 denotes significant difference.