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. 2022 Feb 3;17(2):e0253638. doi: 10.1371/journal.pone.0253638

Table 2. Protein specificity of anti-SARS-CoV-2 antibodies detected in healthy individuals non-vaccinated and never diagnosed positively for SARS-CoV-2 infection.

Number of individuals demonstrating indicated specificity was presented.

anti-NCP anti-RBD anti-S2 anti-E anti-ACE2 anti-PLPro
IgG 136 128 135 1 1 3
IgA 182 136 121 14 20 14

NCP- nucleocapsid protein, RBD-receptor binding domain within Spike protein, S2- domain S2 within Spike protein, E- envelope protein, ACE2- angiotensin-converting enzyme 2, PLPro- papain-like protease.