Table 1:
A summary of clinical trials investigating CAR-T cells with humanized targeting domains.
| Clinical trial identifier | Target antigen | Indication(s) | Number of patients | Start date | Completion date | Phase | Ref. |
|---|---|---|---|---|---|---|---|
| NCT02782351 | CD19 | R/R B-cell malignancies | 50 | May 2016 | December 2018 | I / II | [29] |
| NCT02349698 | CD19 | B-cell leukemia and lymphoma | 45 | December 2014 | December 2023 | I / II | [30] |
| NCT02374333 | CD19 | B-ALL and DLBCL | 85 | March 2014 | November 2022 | I | [38] |
| NCT04532268 | CD19 | B-ALL and B-cell NHL | 72 | August 2020 | August 2026 | Early Phase I | - |