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. 2022 Feb 4;101(5):1027–1038. doi: 10.1016/j.kint.2021.12.029

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© 2022 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Correlations between serologic and cellular immune compartments against (spike) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen. IgG titters against antigen S and circulating (receptor binding domain [RBD]–spike)-specific memory B cell (mBc) frequencies exhibited a significant positive correlation (r = 0.355, P = 0.003), which was fundamentally driven by immunocompetent (IC) subjects (r = 0.548, P < 0.001). A similar pattern was observed between spike-specific IgG titers and the different (spike)SARS-CoV-2–reactive cytokine-producing T-cell frequencies but for IL-21 (data not shown) was mainly observed within IC individuals (interferon-γ [IFN-γ]: r = 0.358, P = 0.013; interleukin-2 [IL-2]: r = 0.404, P = 0.005; and IFN-γ/IL-2: r = 0.458, P = 0.001). PBMC, peripheral blood mononuclear cell; SFU, spot forming unit; SOT, solid organ transplant.