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. 2022 Feb 4;101(5):1027–1038. doi: 10.1016/j.kint.2021.12.029

Figure 8.

Figure 8

Dot plots showing the proportion of subjects with detectable responses at the different immune compartments according to disease severity. Humoral memory (H) + T-cell memory (T) = detectable (receptor binding domain [RBD]–spike)-specific memory B cell (mBC) and/or anti-spike IgG and spike-specific interferon-γ (IFN-γ)–producing T cells. Humoral memory = detectable (RBD-spike)-specific mBC or anti-spike IgG. T-cell memory = detectable spike-specific IFN-γ-producing T cells. None (N): no detectable humoral or cellular immunity. SEVERE group: 80% (H+T), 17.5% (H), 2.5% (T), 0% (N); MILD group: 78.9% (H+T), 7.9% (H), 7.9% (T), 5.3% (N); asymptomatic (ASYMP) group: 26.3% (H+T), 26.3% (H), 5.3% (T), 42.1% (N); P < 0.001.