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. 2022 Jan 27;2022:6227330. doi: 10.1155/2022/6227330

Figure 2.

Figure 2

PCI34051 regulates renin-angiotensin system-related genes in the cardiac and pulmonary tissues of transverse aortic constriction (TAC) mice. (a–d) Cardiac and pulmonary mRNA levels of Ace1 and Ace2 in the sham+vehicle, sham+PCI34051 (10 mg/kg bodyweight/day), TAC+vehicle, and TAC+PCI34051 (3, 10, or 30 mg/kg bodyweight/day) groups (n = 5–6) were examined using quantitative real-time polymerase chain reaction (qRT-PCR). (e) Representative western blot images of Ace1 and Ace2 in cardiac tissues. (f, g) Quantification of Ace1 and Ace2 levels (n = 5–6). (h) Representative western blot images of Ace1 and Ace2 in the pulmonary tissues. (i, j) Quantification of Ace1 and Ace2 levels (n = 5–6). (k–n) Cardiac and pulmonary mRNA levels of Agtr1 and Agtr2 were determined using qRT-PCR and normalized to those of Gapdh (n = 5–6).