Skip to main content
. 2022 Jan 27;2022:3777351. doi: 10.1155/2022/3777351

Figure 2.

Figure 2

Treatment with the P2X7R inhibitor A-438079 improved LPS-induced decline in tight junction protein expression in the mouse hippocampus. (a) The expression levels of ZO-1, P2X7R, and Occludin were detected by Western Blot. Respective bands with Tubulin as loading controls are shown. (b) The expression of P2X7R was significantly increased in the hippocampus of mice after intraperitoneal injection of LPS. All data are expressed as mean ± SD. ∗P < 0.05 vs. control. (c) and (d) LPS significantly inhibited the expression of tight junction proteins ZO-1 and Occludin in the hippocampal tissues of mice, while A-438079 reversed this effect. All data are expressed as mean ± SD. ∗P < 0.05 vs. control, and #P < 0.05 vs. LPS group.