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. 2022 Jan 31;7(2):251–261. doi: 10.1038/s41564-021-01054-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 7 — ML phylogenetic tree of 806S. flexneri GEMS and 236 publicly available genomes, based on core genome SNPs is displayed on the left. The six subtypes identified among the population are highlighted in different colours according to the inlaid key. The alternating grey and purple colour blocks displayed above the top panel represents the six antigen vaccine candidates assessed in the current study. The matrix in the center demonstrates presence (in black) of aa variation for each antigen vaccine. Only variable sites are displayed. The full list of variable sites represented are available in Supplementary Table 8.