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. 2022 Jan 31;7(2):251–261. doi: 10.1038/s41564-021-01054-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a, Detection of known AMR genetic determinants associated with drug class grouped by region. Each cell in the heatmap represents the percentage of isolates from a region containing genetic determinants associated with resistance to a drug class. Genetic determinant conferring reduced susceptibility to quinolone is indicated with an asterisk. b, The genetic convergent evolution of ciprofloxacin resistance in S. flexneri and S. sonnei. The presence of multiple monophyletic clades of QRDR mutations (single, double or triple according to the inlaid key) conferring reduced susceptibility or resistance to ciprofloxacin is shown in the outer ring. Figures for S. boydii and S. dysenteriae are shown in Supplementary Fig. 10.

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