Figure 3.

Decline of central residual effective radius as a function of time. (A) Decline of the central residual effective radius as a function of time in 210 individual eyes. Each dashed line represents 1 eye, and the solid circles on the dotted line represent the central residual effective radius at baseline and subsequent follow-up(s). At time 0, the central residual sizes varied widely across different eyes, suggesting that these eyes might have different durations of geographic atrophy (GA) in the central zone. Despite the large interindividual variations, the central residual effective radius declined over time (r2 = 0.16). (B) Same data after adding a horizontal translation factors (expressed in years) to each dataset (ie, each dotted line) in (A) to account for different baseline durations of atrophy in the central zone among individual eyes. Horizontal axis now represents the inferred duration of GA in the central zone rather than the follow-up time. After the introduction of the horizontal translation factors, datasets now followed along a straight line with a decline rate of 0.038 mm/year (r2 = 0.80). The decline rate in central residual effective radius appeared to be relatively constant over the elapsed time.