Fig. 2.
Distribution of individual mean vosoritide AUC0-∞ in plasma by serum TAb status (negative or positive) in the phase III study. The line inside the box represents the median and the box represents the limits of the middle half of the data. The range of the box, from the first quartile (Q1) to the third quartile (Q3), defines the IQR. The standard span of the data is defined within the range from Q1 − 1.5 × IQR to Q3+1.5 × IQR. Whiskers are drawn to the nearest value not beyond the range of the standard span; points beyond are drawn as individual open circles. Distribution of the individual mean vosoritide Cmax is similar and is shown in Fig. S4 of the ESM. AUC0-∞ area under the plasma concentration-time curve from time zero to infinity, TAb total anti-vosoritide antibody, IQR interquartile range, Cmax maximum observed plasma concentration, ESM electronic supplementary material