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. 2021 Aug 25;25(1):129–143. doi: 10.1007/s10456-021-09816-3

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© The Author(s) 2021

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Fig. 6 — PFKFB3 deficiency in endothelial cells reduces intraplaque hemorrhages (IPH) in vein graft lesions. A Representative vein graft lesions stained with anti-TER-119. TER-119 staining (red) allows detection of erythrocytes. Scale bar = 200 μm. B Examples of atherosclerotic lesions in vein grafts of ApoE^−/−PFKFB3^fl/fl and ApoE^−/−PFKFB3^ECKO mice stained with anti-CD31, anti-TER-119, and DAPI. An overlay of the three stainings is also shown as well as a magnification (20x) of the boxed areas showing erythrocyte extravasation. Scale bar = 500 μm (4x) or 100 μm (20x). C Quantification of IPH. *P = 0.034 versus ApoE^−/−PFKFB3^fl/fl. Independent samples t test; n = 7 (ApoE^−/−PFKFB3^fl/fl) or n = 8 (ApoE^−/−PFKFB3^ECKO)