Figure 3.

TCR recognition of autoantigens presented by DQ7. Figure shows a ribbon rendering of DQ7 with bound superimposed BP peptide antigens, being recognized by a TCR. BP peptide antigens are colored in yellow (FNWLPPGKPMGYRV), green (DNVIRKYGDPGSLFG), red (PAKAIAAVKSGGAVL) and black (LERIRRSILPYGDSM), respectively. DQ7 α and β chains are colored in purple and grey, respectively, while the α and β chains of the TCR are shown in cyan and blue, respectively. The TCR was positioned after superimposing the tertiary structure of DQ7 models with that in PDB 5KS9 corresponding to HLA-DQ8 with a bound glia-α1 peptide in complex with a TCR. Tertiary structures of peptide-DQ7 complexes were obtained by homology modeling (details in Methods) and superimposition of tertiary structures and molecular graphic representations were obtained using PyMol Molecular Graphics System, Version 2.0 Schrödinger, LLC.