Fig. 3.
Schematic diagram of the PK/PD model. CL1 allopurinol clearance, V1 allopurinol volume of distribution, CL2 oxypurinol clearance, V2 oxypurinol volume of distribution, fm formation fraction, Kin3 hypoxanthine production rate, K34 hypoxanthine to xanthine metabolism rate, K45 xanthine to uric acid metabolism rate, Kout5 uric acid elimination rate, EBASE3 hypoxanthine baseline value, EBASE4 xanthine baseline value, EBASE5 uric acid baseline value, Init3D disease-related hypoxanthine initial value, Init4D disease-related xanthine initial value, Init5D disease-related uric acid initial value, EFF xanthine oxidase inhibition by allopurinol and oxypurinol, IV intravenous infusion, XO xanthine oxidase, PK pharmacokinetic, PD pharmacodynamic