| The dosing regimen applied in the ALBINO trial leads to the targeted xanthine oxidase inhibition in hypoxic-ischemic encephalopathy (HIE) neonates treated with or without therapeutic hypothermia (TH). |
| The disease-related autoinhibition effect of allopurinol metabolism, as well as higher hypoxanthine, xanthine and uric acid initial levels, were identified in HIE neonates. |
| Clearances of allopurinol and oxypurinol were not significantly different between TH and non-TH patients. |
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