Table 5.
The diagnostic value of mNGS compared to conventional methods in non-blood samples in FUO.
| Disease | Samples | Sample type | NGS(+)/CM(+) | NGS(+)/CM(−) | NGS(−)/CM(+) | NGS(−)/CM(−) | PEDRconventional methods (%) |
|---|---|---|---|---|---|---|---|
| Infection | 45 | / | 8 | 9 | 2 | 26 | 20% |
| bloodstream infection | 13 | / | 0 | 1 | 1 | 11 | 7.70% |
| 4 | CSF | 0 | 0 | 0 | 4 | 0.00% | |
| 4 | Tissue | 0 | 1 | 1 | 2 | 25.00% | |
| 3 | Puncture fluid | 0 | 0 | 0 | 3 | 0.00% | |
| 1 | Pleural fluid | 0 | 0 | 0 | 1 | 0.00% | |
| 1 | BALF | 0 | 0 | 0 | 1 | 0.00% | |
| Non-blood stream infection | 32 | / | 8 | 8 | 0 | 16 | 26.20% |
| 12 | Tissue | 2 | 3 | 0 | 7 | 25.00% | |
| 9 | CSF | 1 | 2 | 0 | 6 | 22.22% | |
| 2 | Puncture fluid | 2 | 0 | 0 | 0 | 0.00% | |
| 4 | Sputum | 1 | 1 | 0 | 2 | 25.00% | |
| 3 | BALF | 2 | 0 | 0 | 1 | 0.00% | |
| 1 | Urine | 0 | 1 | 0 | 0 | 100.00% | |
| 1 | Pleural fluid | 0 | 1 | 0 | 0 | 100.00% |