Table 2.
Operative characteristics.
| A | B | C | P-value | ||||
|---|---|---|---|---|---|---|---|
| Characteristic | SCS SCD N = 45 |
SCS ECD N = 21 |
EVLP N = 22 |
KW or χ2 | A vs B | A vs C | B vs C |
| Total preservation time (minutes) | 409 [373, 506] | 438 [383, 492] | 857 [760, 1103] | <0.0001 | >0.99 | <0.0001 | <0.0001 |
| Pre-EVLP preservation time | 100 [52, 232] | ||||||
| Post-EVLP preservation time | 304 [238, 406] | ||||||
| EVLP time (minutes) | 313 [239, 448] | ||||||
| Cold ischemic time (minutes) | 409 [373, 506] | 438 [383, 492] | 515 [305, 622] | 0.48 | |||
| EVLP device | |||||||
| Lung Bioengineering | 4 (18.2%) | ||||||
| XVIVO Perfusion System | 6 (27.3%) | ||||||
| TransMedics OCS | 12 (54.5%) | ||||||
| Operative duration (minutes) | 407 [368, 477] | 403 [350, 494] | 424 [349, 524] | 0.99 | |||
| Operation start time | 0.88 | ||||||
| 06:00–17:59 | 21 (46.7%) | 10 (47.6%) | 9 (40.9%) | ||||
| 18:00–05:59 | 24 (53.3%) | 11 (52.3%) | 13 (59.1%) | ||||
| Cardiopulmonary bypass used | 13 (28.9%) | 3 (14.3%) | 5 (22.7%) | 0.43 | |||
| Bypass time (minutes)a | 242 [169, 317] | 275 [243, 415] | 329 [290, 337] | 0.37 | |||
| Concomitant procedure | 3 (6.7%) | 0 (0.0%) | 3 (13.6%) | 0.21 | |||
| Atrial septal defect repair | 1 (2.2%) | 0 (0.0%) | 2 (9.1%) | 0.21 | |||
| Coronary artery bypass | 2 (4.4%) | 0 (0.0%) | 1 (4.5%) | 0.97 | |||
| Transfusion (units) | |||||||
| Packed red blood cells | 1.00 [0.00, 3.00] | 1.00 [0.00, 2.50] | 2.00 [0.75, 4.00] | 0.20 | |||
| Fresh frozen plasma | 0.00 [0.00, 1.00] | 0.00 [0.00, 0.00] | 0.00 [0.00, 1.75] | 0.61 | |||
| Cryoprecipitate | 0.00 [0.00, 1.00] | 0.00 [0.00, 0.50] | 0.00 [0.00, 1.25] | 0.44 | |||
| Platelets | 0.00 [0.00, 1.00] | 0.00 [0.00, 0.00] | 0.00 [0.00, 1.00] | 0.40 | |||
| Donor/recipient weight ratio | 1.02 [0.92, 1.23] | 1.08 [0.94, 1.21] | 1.07 [0.95, 1.61] | 0.55 | |||
| Serologies | |||||||
| Donor EBV positive | 41 (91.1%) | 20 (95.2%) | 20 (90.9%) | 0.83 | |||
| Donor CMV positive | 29 (64.4%) | 8 (38.1%) | 14 (63.6%) | 0.11 | |||
| Recipient CMV positive | 21 (46.7%) | 12 (57.1%) | 13 (59.1%) | 0.56 | |||
| CMV mismatch (D+/R−) | 16 (35.6%) | 5 (23.8%) | 6 (27.3%) | 0.58 | |||
| Transplant type (bilateral) | 45 (100%) | 21 (100%) | 22 (100%) | n/a | |||
Median (interquartile range) for continuous variables and count (percent) for categorical variables.
CMV, cytomegalovirus. EBV, Epstein-Barr virus. ECD, extended-criteria donor. EVLP, ex-vivo lung perfusion. KW, Kruskal-Wallis. OCS, Organ Care System. SCD, standard-criteria donor. SCS, static cold storage.
a
Among those who underwent lung transplantation on full cardiopulmonary bypass.