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. Author manuscript; available in PMC: 2023 Feb 1.
Published in final edited form as: Am J Transplant. 2021 Oct 12;22(2):427–437. doi: 10.1111/ajt.16852

Figure 1. IL-6 deficiency prevents accelerated cardiac allograft rejection in hyperlipidemic recipients.

Figure 1.

Groups of mice were fed either high fat diet (HFD) or normal chow (NC) for a minimum of four weeks prior to transplantation with allogeneic bm12 cardiac grafts. Shown is graft survival in ApoE−/−IL-6+/+ recipient mice fed HFD (squares, MST = 48 days, n = 9), ApoE+/+IL-6+/+ recipient mice fed NC (circles, MST > 100 days, n = 5), and ApoE−/−IL-6−/− recipient mice fed HFD (upright triangles, MST > 100 days, n = 8, P = 0.004 vs ApoE−/− HFD recipients). Significance was determined by log-rank (Mantel-Cox) test.