TABLE 1.

Clinical features and neuropathological associations of posterior cortical atrophy and corticobasal syndrome^a

Feature	Posterior cortical atrophy	Corticobasal syndrome
Cognitive and motor features	Visual-perceptual: space perception deficit, simultanagnosia, object perception deficit, environmental agnosia, alexia, apperceptive prosopagnosia, and homonymous visual field defect	Motor: limb rigidity or akinesia, limb dystonia, and limb myoclonus
	Visual-motor: constructional dyspraxia, oculomotor apraxia, optic ataxia, and dressing apraxia
	Other: left/right disorientation, acalculia, limb apraxia, agraphia, and finger agnosia	Higher cortical features: limb or orobuccal apraxia, cortical sensory deficit, and alien limb phenomena
Imaging features (MRI, FDG-PET, SPECT)	Predominant occipito-parietal or occipito-temporal atrophy, and hypometabolism or hypoperfusion	Asymmetric perirolandic, posterior frontal, parietal atrophy, and hypometabolism or hypoperfusion
Neuropathological associations	AD>CBD, LBD, TDP, JCD	CBD>PSP, AD, TDP

^aConsensus diagnostic criteria for posterior cortical atrophy per Crutch et al. (7) require at least three cognitive features and relative sparing of anterograde memory, speech-nonvisual language functions, executive functions, behavior, and personality. Diagnostic criteria for probable corticobasal syndrome per Armstrong et al. (8) require asymmetric presentation of at least two motor features and at least two higher cortical features. AD=Alzheimer’s disease; CBD=corticobasal degeneration; FDG-PET=[¹⁸]F-fluorodexoxyglucose positron emission tomography; JCD=Jakob-Creutzfeldt disease; LBD=Lewy body disease; PSP=progressive supranuclear palsy; SPECT=single-photon emission computed tomography; TDP=TDP–43 proteinopathy.