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. 2022 Feb 3;12:1875. doi: 10.1038/s41598-021-04482-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Odor-evoked activity in the olfactory receptor neurons (input) recorded with ArcLight in OMP-ArcLight transgenic mice. (A) Baseline fluorescence from four different preparations. (B) Single-trial recordings from the glomeruli indicated in panel A showing the ability of ArcLight to track the animal’s respiration. The traces are low pass filtered at 12 Hz. Each row is from a different preparation. Scale bars all indicate −1% ∆F/F. (C) Time versus amplitude plots for the ArcLight and respiration trace from the bottom preparation in panels A, B. (D) Time versus frequency graphs of the corresponding traces in panel C. (E) Average power at the respiratory frequency prior to and during odor presentation for the examples in A, B (left panel), and for a population of glomeruli (right panel). *p < 0.05; **p < 0.001.