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. 2022 Feb 3;12:1875. doi: 10.1038/s41598-021-04482-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Olfactory receptor neuron glomeruli exhibit minimal adaptation in response to repeated 3-s presentations separated by a 6-s interval. (A) Activity map of neuronal activity evoked by 1.83% of saturated vapor (methyl valerate) in response to the 1st (left panel) and 3rd (right panel) odor presentation. The maps are scaled to the same min and max range. (B) Fluorescence traces from the two glomeruli indicated in panel A. The traces are cropped to illustrate the response to the 1st (left column) and 3rd (right column) odor presentation and are low pass filtered at 12 Hz. (C) Population normalized response amplitude of repeated odor presentations at four different odor concentrations. Each line indicates the mean response of all activated glomeruli to an odor from a single preparation. The mean ± s.e.m. responses across all preparations are shown as thick black lines. *p < 0.01.