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. 2022 Feb 3;12:1835. doi: 10.1038/s41598-022-05901-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Correlations of disease symptoms with beta–gamma phase–amplitude coupling (PAC) and with beta-band or gamma-band power in the sensorimotor cortex. (A) The averaged synchronization index (SI) values for the sensorimotor cortex, in which significant PAC is present, were plotted against the sum of the MDS-UPDRS-III scores for akinesia. (B,C) The averaged Z scores of beta-band power (B) and gamma-band power (C) in the sensorimotor cortex were plotted against the sum of the MDS-UPDRS-III scores for akinesia. In the plots, each dot represents a patient with Parkinson’s disease (n = 23); dashed least-squares lines are also shown. MDS-UPDRS-III = Movement Disorder Society–sponsored revision of the Unified Parkinson’s Disease Rating Scale, part III.