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. 2022 Feb 3;12:1911. doi: 10.1038/s41598-022-05841-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Ultrahigh-content imaging validates expression of target candidates on healthy human tissues to predict safety and toxicity of target candidates. Fresh-frozen human tissues were sliced and fixed with acetone. The subsequent screening was performed on the MACSima Imaging Platform by employing a sequential staining of antibodies. Healthy human tissues, i.e. medulla oblongata, ovary, pancreas, colon, kidney, lung, thyroid gland, and pituitary gland, were analyzed for the expression of glioblastoma target candidates (left panel), GD2 is shown in red, EGFR in green, cMET in blue, and DAPI in white; ovarian cancer target candidates (middle panel), EPCAM is shown in red, THY1 in green, and DAPI in white; pancreatic cancer target candidates (right panel), TSPAN8 is shown in red, CLA in green, CDCP1 in blue, and DAPI in white. Scale bar represents 100 µm.