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. 2022 Jan 5;54(1):12–22. doi: 10.1038/s12276-021-00718-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Enrichment of cancer hallmark gene sets from the CancerSEA database for functional (F)-eDMR target genes. The dashed line indicates the significance threshold (q-value < 0.05). b Enrichment of each category of cancer-associated genes from the CancerMine database for F-pDMR and F-eDMR target genes. The dashed line indicates the significance threshold (q-value < 0.05). c Enrichment of Reactome pathway gene sets for F-pDMR and F-eDMR target genes. The bar graph indicates the number of significantly enriched pathways (q-value < 0.01) for each category. d Enrichment of cancer-testis genes for F-pDMR and F-eDMR target genes.