Table 2.
The compositions and VAFs of variant sets of thirty-nine products.
| Category | Product | VAF of variant set (Het%/Hom%) | # SNV | # INDEL | Total | ||||
|---|---|---|---|---|---|---|---|---|---|
| V1 | V2 | V3 | V4 | V5 | |||||
| M1 | M1-1 | 4.0/8.0 | 1.0/2.0 | — | — | — | 9,339 | 318 | 9,657 |
| M1-2 | 4.0/8.0 | 3.0/6.0 | — | — | — | 9,339 | 318 | 9,657 | |
| M1-3 | 4.0/8.0 | 25.0/50.0 | — | — | — | 9,339 | 318 | 9,657 | |
| M1-4 | 9.6/19.2 | 1.0/2.0 | — | — | — | 9,339 | 318 | 9,657 | |
| M1-5 | 9.6/19.2 | 3.0/6.0 | — | — | — | 9,339 | 318 | 9,657 | |
| M1-6 | 9.6/19.2 | 25.0/50.0 | — | — | — | 9,339 | 318 | 9,657 | |
| M1-7 | 28.0/56.0 | 1.0/2.0 | — | — | — | 9,339 | 318 | 9,657 | |
| M1-8 | 28.0/56.0 | 3.0/6.0 | — | — | — | 9,339 | 318 | 9,657 | |
| M1-9 | 4.0/8.0 | 0.5/1.0 | — | — | — | 9,339 | 318 | 9,657 | |
| M2 | M2-1 | 4.0/8.0 | — | 5.0/10.0 | 0.5/1.0 | — | 7,333 | 233 | 7,566 |
| M2-2 | 4.0/8.0 | — | 5.0/10.0 | 3.0/6.0 | — | 7,333 | 233 | 7,566 | |
| M2-3 | 4.0/8.0 | — | 8.0/16.0 | 0.5/1.0 | — | 7,333 | 233 | 7,566 | |
| M2-4 | 4.0/8.0 | — | 8.0/16.0 | 3.0/6.0 | — | 7,333 | 233 | 7,566 | |
| M2-5 | 9.6/19.2 | — | 5.0/10.0 | 0.5/1.0 | — | 7,333 | 233 | 7,566 | |
| M2-6 | 9.6/19.2 | — | 5.0/10.0 | 3.0/6.0 | — | 7,333 | 233 | 7,566 | |
| M2-7 | 9.6/19.2 | — | 8.0/16.0 | 0.5/1.0 | — | 7,333 | 233 | 7,566 | |
| M2-8 | 9.6/19.2 | — | 8.0/16.0 | 3.0/6.0 | — | 7,333 | 233 | 7,566 | |
| M2-9 | 28.0/56.0 | — | 5.0/10.0 | 0.5/1.0 | — | 7,333 | 233 | 7,566 | |
| M2-10 | 28.0/56.0 | — | 5.0/10.0 | 3.0/6.0 | — | 7,333 | 233 | 7,566 | |
| M2-11 | 28.0/56.0 | — | 8.0/16.0 | 0.5/1.0 | — | 7,333 | 233 | 7,566 | |
| M2-12 | 28.0/56.0 | — | 8.0/16.0 | 3.0/6.0 | — | 7,333 | 233 | 7,566 | |
| M3 | M3-1 | 4.0/8.0 | — | 7.5/15.0 | — | 1.0/2.0 | 11,251 | 355 | 11,606 |
| M3-2 | 4.0/8.0 | — | 7.5/15.0 | — | 2.0/4.0 | 11,251 | 355 | 11,606 | |
| M3-3 | 4.0/8.0 | — | 7.5/15.0 | — | 4.0/8.0 | 11,251 | 355 | 11,606 | |
| M3-4 | 4.0/8.0 | — | 12.0/24.0 | — | 1.0/2.0 | 11,251 | 355 | 11,606 | |
| M3-5 | 4.0/8.0 | — | 12.0/24.0 | — | 2.0/4.0 | 11,251 | 355 | 11,606 | |
| M3-6 | 4.0/8.0 | — | 12.0/24.0 | — | 4.0/8.0 | 11,251 | 355 | 11,606 | |
| M3-7 | 9.6/19.2 | — | 7.5/15.0 | — | 1.0/2.0 | 11,251 | 355 | 11,606 | |
| M3-8 | 9.6/19.2 | — | 7.5/15.0 | — | 2.0/4.0 | 11,251 | 355 | 11,606 | |
| M3-9 | 9.6/19.2 | — | 7.5/15.0 | — | 4.0/8.0 | 11,251 | 355 | 11,606 | |
| M3-10 | 9.6/19.2 | — | 16.0/32.0 | — | 1.0/2.0 | 11,251 | 355 | 11,606 | |
| M3-11 | 9.6/19.2 | — | 16.0/32.0 | — | 2.0/4.0 | 11,251 | 355 | 11,606 | |
| M3-12 | 9.6/19.2 | — | 16.0/32.0 | — | 4.0/8.0 | 11,251 | 355 | 11,606 | |
| M3-13 | 28.0/56.0 | — | 10.0/20.0 | — | 1.0/2.0 | 11,251 | 355 | 11,606 | |
| M3-14 | 28.0/56.0 | — | 10.0/20.0 | — | 2.0/4.0 | 11,251 | 355 | 11,606 | |
| M3-15 | 28.0/56.0 | — | 10.0/20.0 | — | 4.0/8.0 | 11,251 | 355 | 11,606 | |
| M3-16 | 28.0/56.0 | — | 16.0/32.0 | — | 1.0/2.0 | 11,251 | 355 | 11,606 | |
| M3-17 | 28.0/56.0 | — | 16.0/32.0 | — | 2.0/4.0 | 11,251 | 355 | 11,606 | |
| M3-18 | 28.0/56.0 | — | 16.0/32.0 | — | 4.0/8.0 | 11,251 | 355 | 11,606 | |
| Total | 374,565 | 12,048 | 386,613 | ||||||
M1, M2, and M3 refer to the three classes depending on the constituent cell lines and 9, 12, 18 products were generated respectively, according to different mixing ratio. V1 RPE, V2 CCD-18co, V3 HBEC30-KT, V4 THLE-2, V5 FHC, VAF variant allele frequency, Het heterozygous, Hom homozygous.