Table 3.
Univariate and multivariable logistic regression analyses for severe outcome.
| Variable | Univariate | Multivariable | p value (individual AUC vs. model AUC) | ||||
|---|---|---|---|---|---|---|---|
| Odds ratio | 95% CI | p value | Odds ratio | 95% CI | p value | ||
| Galectin-3 (binary) | 7.94 | (3.75–16.82) | < 0.0001 | 3.68 | (1.47–9.20) | < 0.01 | < 0.001 |
| CRP | 1.11 | (1.07–1.16) | < 0.0001 | 1.05 | (1.00–1.11) | 0.04 | 0.03 |
| Albumin | 0.14 | (0.06–0.33) | < 0.0001 | 0.35 | (0.13–0.89) | 0.03 | 0.03 |
| Critical disease (CT pulmonary affection > 50%) | 7.86 | (3.25–19.03) | < 0.0001 | 4.04 | (1.17–13.97) | 0.03 | < 0.0001 |
| Gender (male) | 1.99 | (0.93–4.25) | 0.08 | ||||
| Age | 1.02 | (1.00–1.05) | 0.10 | ||||
| Diabetes | 1.62 | (0.74–3.57) | 0.23 | ||||
| Hypertension | 0.98 | (0.48–2.01) | 0.96 | ||||
| Obesity (BMI ≥ 30) | 1.14 | (0.59–2.21) | 0.71 | ||||
| NLR | 1.05 | (1.02–1.09) | < 0.01 | ||||
| Neutrophil count | 1.15 | (1.07–1.23) | < 0.001 | ||||
| Ferritin | 1.00 | (1.07–1.23) | < 0.01 | ||||
| Lymphocyte count | 0.63 | (0.28–1.42) | 0.27 | ||||
| Platelets | 1.00 | (1.00–1.00) | 0.89 | ||||
| D-Dimer | 1.00 | (1.00–1.00) | 0.03 | ||||
| Fibrinogen | 1.00 | (1.00–1.01) | < 0.01 | ||||
| INR | 2.06 | (1.01–4.24) | 0.05 | ||||
| Triglycerides | 1.01 | (1.00–1.01) | 0.02 | ||||
| AST | 1.01 | (1.00–1.02) | 0.03 | ||||
Galectin-3 was analyzed as a binary variable according to its non-linear relationship with severe outcomes (> 30.99 ng/mL = 1, < 30.99 ng/mL = 0). Only variables with a p value < 0.20 after univariate analyses were further evaluated in multivariable analyses. The AUC of the final model was compared against that of each independent predictor with DeLong’s test for correlated ROC curves. Bold values represent p < 0.05.