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. 2022 Feb 3;13:646. doi: 10.1038/s41467-022-28204-z

Fig. 2. Capsaicin induces PMA via CGRP and CLR/RAMP1 in Schwann cells.

Fig. 2

a Acute nociception and (b) PMA after periorbital injection of capsaicin (CPS) or vehicle in C57BL/6 J mice. c Acute nociception and (d) PMA after CPS (50 pmol) or vehicle in Trpv1+/+ and Trpv1−/− mice. e Acute nociception and (f) PMA after CPS (50 pmol) or vehicle in C57BL/6 J mice pretreated with capsazepine (CPZ, 100 pmol) or vehicle. g, h PMA after periorbital SP (3.5 nmol), CPS (50 pmol) or vehicle in C57BL/6 J mice pretreated (0.5 h) with L-733,060 (20 nmol) or vehicle. i, j PMA after CPS (50 pmol) or vehicle in C57BL/6 J mice pretreated (0.5 h) with olcegepant (1 nmol) or CGRP8-37 (10 nmol) or vehicle. k PMA after CPS (50 pmol) or vehicle in Plp1-CreERT+/Ramp1fl/fl or Control mice treated with periorbital 4-OHT or vehicle. l PMA after periorbital CGRP (1.5 nmol) or vehicle and (m) acute nociceptive response and PMA after periorbital CPS (50 pmol) or vehicle in Adv-Cre+/Ramp1fl/fl or Control mice. n PMA induced by intraperitoneal (i.p.) CGRP (0.1 mg/kg) or vehicle in Adv-Cre+/Ramp1fl/fl or Control mice. Mean±SEM., n = 8 mice per group. **P < 0.01, ***P < 0.001 vs. Veh/Veh, Trpv1+/+-Veh and Control-Veh; §P < 0.05, §§P < 0.01, §§§P < 0.001 vs. Trpv1+/+-CPS, CPS/Veh, SP/Veh, Control-CPS, Control-CGRP. 1-way (a, c, e and m left panel) or 2-way (b, d, f–l, m right panel and n) ANOVA, Bonferroni correction. Source data are provided as a Source Data file.