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. 2022 Feb 3;12:1839. doi: 10.1038/s41598-022-05771-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Individual CD73 responses (A) in the active vs. placebo arms (no significant difference), (B) in patients that survived vs. patients that died by D30 (i.e. all study patients), mean max CD73 achieved between groups 6.09 ng/mL (SD, 4.95 ng/mL) correspondingly for patient without glucocorticoids vs. 2.37 ng/mL (SD, 0.90 ng/mL) (Satterthwaite t-test, P < 0.001), and (C) in patients that received vs. did not receive overlapping glucocorticoids with IV IFN beta-1a (i.e. active arm only), mean max CD73 achieved between groups 6.52 ng/mL (SD, 5.37 ng/mL) for patient without glucocorticoids vs. with glucocorticoids 2.37 ng/mL (SD, 0.91 ng/mL) (Satterthwaite t-test, P = 0.0026).