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. 2022 Feb 3;13(2):109. doi: 10.1038/s41419-022-04542-0

Fig. 1. Elevated expression of LINC01123 and B7–H3 in HNSCC is linked to poor prognosis, and the potential miRNA link between LINC01123 and B7–H3 was predicted to be miR-214-3P via bioinformatic methods.

Fig. 1

A Heat map with hierarchical clustering. Blue and red indicate low and high expression levels, respectively. B Venn diagram of upregulated LncRNAs in four HNSCC cell lines (CAL-27, Fadu, SCC-9, SCC-15) compared with HOEC. C TCGA data of LINC01123 expression in the classical subtype HNSCC tissues (n = 49) and normal tissues (n = 44). D The overall survival rate analysis of LINC01123. E Expression of LINC01123 in HNSCC cell lines (SCC-9, SCC-15, SCC-25, Fadu, CAL-27) and HOEC. F Expression of LINC01123 in HNSCC patient tissues and paracancerous tissues, as detected by qRT-PCR. G TCGA data of B7–H3 expression in HNSCC tissues (n = 519) and normal tissues (n = 44). H The overall survival rate analysis of B7–H3. I B7–H3 is highly expressed in various types of tumor (COAD, DLBC, ESCA, GBM, KIRC, KIRP, LGG, LUSC, PAAD, SKCM, STAD, TGCT, THYM, and UCS). Each dot represents expression of samples. J Subcellular location of LINC01123, as detected by FISH assay. K Prediction of potential miRNA link between LINC01123 and B7–H3. COAD colon adenocarcinoma, DLBC lymphoid neoplasm diffuse large b-cell lymphoma, ESCA esophageal carcinoma, GBM glioblastoma multiforme, KIRC kidney renal clear cell carcinoma, KIRP kidney renal papillary cell carcinoma, LGG brain lower grade glioma, LUSC lung squamous cell carcinoma, PAAD pancreatic adenocarcinoma, SKCM skin cutaneous melanoma, STAD stomach adenocarcinoma, TGCT testicular germ cell tumors, THYM thymoma, UCS uterine carcinosarcoma. The experiment was repeated three times.