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. 2022 Feb 3;13(2):109. doi: 10.1038/s41419-022-04542-0

Fig. 5. Downregulation of LINC01123 or B7–H3 or upregulation of miR-214-3p inhibits the tumorigenicity and immune escape of HNSCC cells in vivo.

Fig. 5

SCC-7 cells were subcutaneously injected into C3H mice and treated with sh-LINC01123, OE-LINC01123, miR-214-3p mimic, miR-214-3p inhibitor, or sh-B7–H3 after tumor formation. A Tumor weights of mice from each group. B Tumor-volume growth curve of each group (n = 3). C Tumor images at week 4. D Immunofluorescence staining of CD4 and CD8 in tumor specimens (×400). E Statistical analysis of CD4 and CD8 immunofluorescence results. F Expression of TNF-α, IFN-γ, perforin, and granzyme B in peripheral blood of tumor-bearing C3H mice, as detected by ELISA. *P < 0.05 versus the blank group. The experiment was repeated three times.