Table 2.
Diagnosis of VZV CNS infection.
| CSF mNGS a | ||
|---|---|---|
| VZV detected (n = 16) | VZV not detected (n = 15) | |
| Clinical diagnosed VZV CNS infection | 7 (43.8) | 6 (40.0%) |
| Positive CSF VZV IgM antibodies | 3 (18.8) | 2 (13.3) |
| CSF VZV nucleic acid test (qualitatively) | 5 (31.5) | 0 (0) |
| CSF VZV nucleic acid test (quantitatively) | 3 (18.8) | 0 (0) |
| Abnormal cerebral MRI | 1 (6.3) | 3 (20) |
CSF, cerebrospinal fluid; mNGS, metagenome next-generation sequencing; VZV, varicella-zoster virus; CNS, central nervous system; MRI, magnetic resonance imaging.
a
The median [interquartile range (IQR)] sequence reads of CSF mNGS is 34.6 (28.8–48.3) millions.