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. 2022 Feb 3;12:1906. doi: 10.1038/s41598-022-05763-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Cladograms reveal microbial phylogenetic branches associated with APOE status in males. Taxa are represented as nodes and are connected by lines based on the phylogenetic relatedness of all taxa present in each experimental cohort. For example, the end node, a. represents the genus Bifodobacterium which is connected to other nodes representing higher level taxa related to Bifodobacterium including; b. the family Bifidobacteriaceae, c. the order Bifidobacteriales, and d. the class Actinobacteria. Many taxa are associated with APOE genetics, with node colors indicating the APOE associated with highest levels of that taxa. Statistical significance reflects both p < 0.05 for Kruskal–Wallis tests and a logarithmic LDA score > 2.0.