Table 2.

Microbiome beta-diversity significantly associated with APOE status in male, but not female, mice.

Beta-diversity (PERMANOVA)
Taxanomic level		3 month
		Males -dominant	Males co-dominant
Feature	p-value	< 0.002	< 0.004
	R2	0.14	0.20
Genus	p-value	< 0.001	< 0.008
	R2	0.15	0.18
Family	p-value	< 0.004	< 0.013
	R2	0.17	0.21
Order	p-value	< 0.004	< 0.015
	R2	0.21	0.24
Class	p-value	< 0.004	< 0.015
	R2	0.21	0.24
Phylum	p-value	< 0.035	< 0.112
	R2	0.12	0.15

The R² values represent the proportion of the variance captured by APOE alleles. The PERMANOVA results were derived from 999 permutations. Values for 5- and 7-month male mice and female mice are contained within Tables S3 and S4.

Significance p-values are in bold font.