Table 3.
Comparisons of oropharyngeal squamous cell carcinoma according to the sub-site.
| Tonsil (n = 51) | BOT (n = 21) | Soft palate (n = 1) | PPW (n = 4) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HPV (+) (n = 40) | HPV (–) (n = 11) | P-value | HPV (+) (n = 13) | HPV (–) (n = 8) | P-value | HPV (+) (n = 0) | HPV (–) (n = 1) | P-value | HPV (+) (n = 1) | HPV (–) (n = 3) | P-value | |
| Mean age | 57.9 ± 10.2 | 64.4 ± 10.6 | 0.073 | 60.8 ± 8.3 | 62.5 ± 11.6 | 0.694 | - | 65.0 | - | 55.0 | 67.7 ± 2.5 | 0.049 |
| Gender | 0.135 | 0.920 | - | - | ||||||||
| Male | 33 (64.7%) | 11 (21.6%) | 10 (47.6%) | 6 (28.6%) | - | 1 (100%) | 1 (25.0%) | 3 (75.0%) | ||||
| Female | 7 (13.7%) | 0 (0%) | 3 (14.3%) | 2 (9.5%) | - | - | 0 (0.0%) | 0 (0.0%) | ||||
| Smoking | 0.290 | 0.477 | - | 0.248 | ||||||||
| Non-smoker | 22 (43.1%) | 8 (15.7%) | 10 (47.6%) | 5 (23.8%) | - | - | 0 (0.0%) | 2 (50.0%) | ||||
| Smoker | 18 (35.3%) | 3 (5.9%) | 3 (14.3%) | 3 (14.3%) | - | 1 (100%) | 1 (25.0%) | 1 (25.0%) | ||||
| Alcohol consumption | 0.861 | 0.965 | - | 0.046 | ||||||||
| No | 23 (45.1%) | 6 (11.8%) | 5 (23.8%) | 3 (14.3%) | - | - | 0 (0.0%) | 3 (75.0%) | ||||
| Yes | 17 (33.3%) | 5 (10.0%) | 8 (38.1%) | 5 (23.8%) | - | 1 (100%) | 1 (25.0%) | 0 (0.0%) | ||||
| T classification | 0.470 | 0.776 | - | 0.505 | ||||||||
| T1/T2 | 33 (64.7%) | 8 (15.7%) | 9 (42.9%) | 6 (28.6%) | - | 1(100%) | 0 (0%) | 1 (25%) | ||||
| T3/T4 | 7 (13.7%) | 3 (5.9%) | 4 (19%) | 2 (9.5%) | - | - | 1 (25%) | 2 (50%) | ||||
| N classification | 0.256 | 0.920 | - | 0.248 | ||||||||
| N0 | 11 (21.6%) | 5 (9.8%) | 3 (14.3%) | 2 (9.5%) | - | 1 (100%) | 0 (0%) | 2 (50%) | ||||
| N+ | 29 (56.9%) | 6 (11.8%) | 10 (47.6%) | 6 (28.6%) | - | - | 1 (25%) | 1 (25%) | ||||
| Stage | <0.001 | 0.006 | - | |||||||||
| I&II | 38 (74.5%) | 3 (5.9%) | 11 (52.4%) | 2 (9.5%) | - | 1 (100%) | - | - | ||||
| III&IV | 2 (3.9%) | 8 (15.7%) | 2 (9.5%) | 6 (28.6%) | - | - | 1 (25%) | 3 (75%) | ||||
| Treatment | 0.596 | 0.072 | - | 0.135 | ||||||||
| Surgery | 5 (9.8%) | 1 (2%) | 2 (9.5%) | 3 (14.3%) | - | - | - | - | ||||
| Surgery + Postop RT or CCRT |
32 (62.7%) | 10 (19.6%) | 7 (33.3%) | 3 (14.3%) | - | 1 (100%) | - | 2 (50%) | ||||
| Definitive RT or CCRT | 3 (5.9%) | 0 (0%) | 0 (0%) | 2 (9.5%) | - | - | 1 (25%) | - | ||||
| Others | - | - | 4 (19.0%) | - | - | - | - | 1 (25%) | ||||
BOT, base of tongue; PPW, posterior pharyngeal wall; HPV, human papilloma virus; RT, radiation therapy; CCRT, concurrent chemoradiation therapy.