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. 2022 Jan 21;12:805758. doi: 10.3389/fphar.2021.805758

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Copyright © 2022 Ribeiro, Aguiar, Scarante, Fusse, de Oliveira, Guimaraes and Campos.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relative hippocampal protein expression and corticosterone levels of stressed mice treated with ESC in combination or not with AM630. Figure shows the expression of pro-BDNF (A). mature BDNF (B). phospho-mTOR (C) and DAGL (D). Representatives of western blot membranes are detailed in the image. Groups were: non-stressed/saline/saline (n = 5); CUS/saline/saline (n = 5); CUS/AM630/saline (n = 4); CUS/saline/ESC (n = 4); and CUS/AM630/ESC (n = 5). ANOVA-two was employed and differences were considered statistically significant when p < 0,05. N = 4-5/group. (# relative to NS/Veh + Veh; * relative to CUS/Veh + Veh and & relative to the CUS-AM630 compared to CUS-AM630 + Esc).