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. 2022 Jan 30;76:103850. doi: 10.1016/j.ebiom.2022.103850

Figure 6.

Fig 6

Detection of residual cancer cells in tumour margins. a, A schematic diagram of the sites of biopsy collection from NSG mice bearing PDX tumours (Mammary fat pad: MFP). b, Genomic DNA was extracted from each specimen and subjected to PCR assays. The box plot shows the values of log(huAlu DNA/mGAPDH DNA), calculated using standardized amounts of huAlu DNA and mGAPDH DNA among the agents. *: P < 0.05, **: P < 0.005 (F test). Results are presented as the mean ± SD. c, Histological analysis of surgical specimens. Representative images (200x) of H&E staining and staining for the proliferative marker Ki-67 to confirm the presence of negative margins in specimens obtained from the ICG-p28 group (top). The specimen obtained from the ICG group (bottom) shows the presence of malignant cells. d, Four weeks after surgical resection, the tumour volumes in each group were determined.