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. 2022 Jan 21;12:742004. doi: 10.3389/fphys.2021.742004

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Copyright © 2022 Ruan, Mendhe, Parker, Kent, Isales, Hill, McGee-Lawrence, Fulzele and Hamrick.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) microRNA response elements (MREs) shown for mouse chromosome 19 region of Malat1 illustrating numerous binding sites for miR-34a-5p. (B) Expression of miR-34a-5p in tibialis anterior muscles of male and female mice 2, 12, and 24 months of age showing a significant increase in mir-34a-5p expression with age. (C) Expression of MALAT1 in tibialis anterior muscles of male and female mice 2, 12, and 24 months of age showing a significant decrease in MALAT1 expression with age. (D) Fluorescent images from tibialis anterior cross-sections stained using RNAscope with probes for MALAT1, PDGFRα, and Pax7 showing decreased MALAT1 levels with age. Arrows in (D) indicate positive labeling. **P < 0.01.